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人才队伍

蒋蔚


研究领域:微生物致病机理和防控技术研究
电话/传真:021-34293397
电子邮件:jiangwei@shvri.ac.cn; jiangweijw99@163.com


个人简历
?蒋蔚,女,副研究员,南京农业大学预防兽医学博士。主要研究方向为人畜共患病病原的致病机理、诊断技术及疫苗研发。已主持包括国家自然科学基金项目、“十三五”国家重点研发计划项目子课题、上海市自然科学基金项目、上海市科学技术委员会科研计划项目等11项。已在"Biosensors and Bioelectronics"、"Applied microbiology and Biotechnology"等国内外期刊杂志上发表研究性论文50余篇,其中第一作者或通讯作者文章共32篇。获得上海市科技成果3项。获得上海市科学进步奖、中国检验检疫学会科技奖等共3个奖项。获得国家发明专利3项。


获奖情况
1.2017年上海市科学进步奖三等奖“动物疫病和动物源性食品安全防控检测中新技术的开发与应用”(20174200-3-R02)。
2.2016年中国检验检疫学会科技奖优秀奖(2016-Y-23-02)。
3.2015年浦东新区科技进步奖三等奖(2015-PDJB3-40-R02)。

主持项目
1.国家自然科学基金项目“T6SS2效应蛋白VP-GntR调控副溶血弧菌致病性的分子机制研究”2018.01-2020.12。
2.“十三五”国家重点研发计划项目子课题“细菌毒力基因组及其致病机制”,2017.07-2020.06。
3.上海市自然科学基金项目“副溶血弧菌VI型分泌系统2核心组分DotU2的致病作用及机制研究”, 2017.05-2020.04。
4.上海市科学技术委员会科研计划项目“实验动物7种重要质量相关病原体检测新技术的研究”,2017.07-2019.06。
5.上海市科学技术委员会科研计划项目子课题“入境动物源性生物制品的生物安全相关标准检测方法建立和管理模式的探索”,2016.08-2019.07。
6.上海市科学技术委员会科研计划项目“水产品中五种主要致病性弧菌高通量快速检测新技术标准研究”, 2014.01-2016.06。
7.上海市科学技术委员会科研计划项目子课题“实验动物重要人畜共患病高通量快速检测新技术的研究”,2016.09-2018.09。
8.中央级公益性科研院所基本科研业务费专项资金项目“利用免疫磁珠分离及ICT/xMAP 技术检测重要弧菌的研究”, 2016.01-2018.12。

代表论文
1.Wei Jiang, Yingchun Liu, Yongjun Chen, PeterChun, Kailing Yao, Xiangan Han, Shaohui Wang,Shengqingyu,Yongjie* Liu,Quan Wang*. A novel dynamic flow immunochromatographic test (DFICT) using gold nanoparticles for the serological detection of Toxoplasma gondii infection in dogs and cats. Biosensors and Bioelectronics. 2015 (72): 133–139. (IF= 7.6133)
2.Wei Jiang, Xiangan Han, Quan Wang, Xintong Li, Li Yi, Yongjie Liu*, Chan Ding*. Vibrio parahaemolyticus enolase is an adhesion-related factor that binds plasminogen and functions as a protective antigen. Applied microbiology and Biotechnology. 2014 98 (11): 4937-48.
3.Wei Jiang, Jun-Xin Xue, Ying-Chun Liu, Tao Li, Xian-Gan Han, Shao-Hui WangYong-Jun Chen Jingjing Qi Sheng-Qing Yu*, Quan Wang*. Identification and characterization of an immunogenic antigen, enolase 2, among excretory/secretory antigens (ESA) of Toxoplasma gondii. Protein Expression and Purification. 2016 (127): 88-97.
4. Wei Jiang, Yan Wang, Yingchun Liu, Tao Li, Shaohui Wang, Xiangan Han, Quan Wang*. Seroepidemiological study of canine Leishmania infantum and Toxoplasma gondii infections in Shanghai, China, and analysis of risk factors. Annals of Agricultural and Environmental Medicine 2016 (23): 491–495.
5. Quan Wang, Yingchun Liu, Mingyan Wang,Yongjun Chen and Wei Jiang*(Corresponding author). A multiplex immunochromatographic test using gold nanoparticles for the rapid and simultaneous detection of four nitrofuran metabolites in fish samples. Analytical and Bioanalytical Chemistry. 2018, 410 (1):223-233.
6. Quan Wang*?, Wei Jiang?(Co-first authors), Yong-Jun Chen, Chun-Ying Liu, Jin-lei Shi and Xin-tong Li. Prevalence of Toxoplasma gondii antibodies, circulating antigens and DNA in stray cats in Shanghai, China. Parasites & Vectors 2012, 5:190.
7. Yuanyuan Shi*? , Wei Jiang?(Co-first authors), Zhiyong Ma and Yafeng Qiu*.A case report of pulmonary tritrichomonosis in a pig. BMC Veterinary Research. 2017,13:348.
8. Junxin Xue, Wei Jiang, Yongjun Chen, Fengju Gong, Minyan Wang, Peng Zeng, Can Xia, Quan Wang, and Kehe Huang. Thioredoxin reductase from Toxoplasma gondii: an essential virulence effector with antioxidant function. FASEB J. 2017.31(10):4447-4457.
9.Junxin?Xue,?Wei?Jiang,?Yongjun?Chen,?Yingchun?Liu,?Huajing?Zhang,?Yan?Xiao,?Yuanbiao?Qiao,Kehe?Huang*?and?Quan?Wang*.?Twenty-six?circulating?antigens?and?two?novel?diagnostic?candidate?molecules?identified?in?the?serum?of?canines?with?experimental?acute?toxoplasmosis.?Parasites & Vectors?(2016)?9:374.
10. Quan Wang*, Wei Jiang, Yong-Jun Chen, Chun-Ying Liu, Jin-lei Shi and Xin-tong Prevalence of Toxoplasma gondii antibodies and DNA in dogs in Shanghai, China. Journal of parasitology . 2011, 97(2):367–369. ?
11.Ying-Chun?Liu,?Wei?Jiang,?Yong-Jun?Chen,?Peng?Zeng,?Feiqun??Xue,?Quan?Wang*.Cytotoxicity?of?mequindox?and?its?metabolites?in?HepG2?cells?in?vitro?and?murine?hepatocytes?in?vivo.?Mutation?Research/Genetic?Toxicology?and?Environmental?Mutagenesis.?2016.797:36-45.?
12.Ying-Chun Liu, Wei Jiang, Yong-Jun Chen, Peng Zeng, Meng Zhang and Quan Wang. Simultaneous detection of four nitrofuran metabolites in honey using high-throughput suspension array technology. Anal. Methods 2015,7: 4097.
13.Ying-Chun Liu, Wei Jiang, Yong-Jun Chen, Yan Xiao, Jin-Lei Shi, Yuan-Biao Qiao, Hua-Jing Zhang, Tao Li, Quan Wang*.A novel chemiluminescent ELISA for detecting furaltadone metabolite, 3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ) in fish, egg, honey and shrimp samples. Journal of Immunological Methods 2013,395: 36-39.
14. Ying-Chun Liu*, Quan Wang*,Wei Jiang, Yong-Jun Chen , Xin-Yu Zhao , Zhen-Yu Jing, Meng Zhang. Simultaneous Determination of Malachite Green, Diethylstilbestrol, Medroxyprogesterone, and 3-Amino-2-Oxazolidone in Synbranchoid Eels by a Protein Microarray MethodFood Anal. Methods 2015, 8:1058–1066.
15.Quan Wang,?* Ying-Chun Liu,? Yong-Jun Chen, Wei Jiang, Jin-Lei Shi, Yan Xiao and Meng Zhang.Development of a direct competitive chemiluminescent ELISA for the detection of nitrofurantoin metabolite 1-amino-hydantoin in fish and honey.Anal. Methods, 2014, 6, 4414
16.白雪瑞,王权,凌娇,万莹,陈永军,方维焕,孙卫东,蒋蔚*(通讯作者).T3SS1和T3SS2 影响副溶血弧菌生物学特性及细胞致病性.微生物学报.2018,58(3):455-466.
17.白雪瑞,王权,陈永军,万莹,凌娇,王亚磊,蒋蔚*(通讯作者).副溶血弧菌ompA 基因缺失株的生物学特性及致病性分析.南京农业大学学报,2018,41(5):902-910.
18.王亚磊,王权,白雪瑞,别闯南,韩先干*,蒋蔚* (并列通讯作者). 副溶血弧菌SH112株OmpA蛋白的高效表达及免疫学特性分析.微生物学报.2019,59(7).
19.凌娇,王权,万莹,白雪瑞,蒋蔚*(并列通讯作者),潘翠玲*.副溶血弧菌和霍乱弧菌双重荧光定量 PCR快速检测方法的建立与应用.畜牧与兽医,2018,50 (4): 93-99.
20.白雪瑞,王权,习润南,凌娇,孙卫东*,蒋蔚*(并列通讯作者).副溶血弧菌极性鞭毛超微结构的电镜观察,畜牧与兽医,2017,49(8):68-71.

授权发明专利
1.蒋蔚,王权,薛俊欣,刘迎春,陈永军,宫枫举,白雪瑞,曾鹏.一种检测弓形虫急性感染的方法及其靶标蛋白,专利号ZL 2015 1 0271816.2
2.蒋蔚,王权,陈永军,刘迎春,史子学,马志永,顾惠明,杨康,宋宁宁,石金磊,李欣彤.一种抗流感病毒的单链抗体及其制备方法和应用,专利号ZL 2012 1 0063870.4
3.王权,薛俊欣,蒋蔚,陈永军,刘迎春,王民燕,宫枫举,程军霞.一种高效检测弓形虫急性感染的方法及其靶标蛋白,专利号ZL 2015 1 0272187.5

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