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单同领


研究领域:新发和再现病毒与宿主相互作用的分子机制

电话/传真:021-34293773

电子邮件:shantongling@shvri.ac.cn

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简历200-500字):

单同领,男,博士,副研究员/硕士生导师,骨干专家2010-2011年访学于加州大学旧金山分校病毒宏基因组学开拓者Delwart Eric实验室在国内率先建立病毒宏基因组学技术平台。主要围绕新发和再现病毒开展工作,以猪流行性腹泻病毒和塞内卡病毒等病原为研究对象,研究病毒复制及其与宿主相互作用分子机制。承担项目:国家十三五重点研发计划课题和国家自然科学基金等。在《Journal?of?Virology》和《Emerging Infectious Diseases》等病毒类杂志发表SCI论文50多篇,其中第一作者和通信作者SCI论文20余篇,2Journal?of?Virology文章分别被选为封面文章和亮点文章。

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工作和学习

2011-至今 ??中国农业科学院滚球盘best365_bet365滚球_365滚球网址是多少;

2010-2011 ?访学于加州大学旧金山分校病毒宏基因组学开拓者Delwart Eric实验室;

2008-2011 ?上海交通大学 博士

2005-2008 ?华中农业大学 硕士

2001-2005 ?河南农业大学 学士

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承担科研项目:?

1. 国家重点研发计划,重要疫源微生物组学研究, 590万元,在研,主持课题;

2. 国家重点研发计划,新发与再现畜禽重大疫病的致病与免疫机制研究, 140万元,在研,子课题;

3. 国家自然科学基金,GSK3介导β-cateninN蛋白调控猪流行性腹泻病毒复制的分子机制研究, 59万元,在研,主持。

4. 国家自然科学基金,新发仔猪腹泻病因的筛选及鉴定, 25万元、结题、主持。

5. 上海市科技兴农重点攻关项目、猪消化道病原口服疫苗研究、32万元、结题、主持子课题。

6. 上海市科技兴农重点攻关项目、上海地区仔猪腹泻病原生态学及防控技术研究、60万元、结题、主持子课题。

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代表论着:

1.?Shan T(单同领), Li L, Simmonds P, Wang C, Moeser A, Delwart E. The fecal virome of pigs on a high-density farm. J Virol. 2011.; 85(22):11697-708. SCI, IF=5.189

2.?Shan TL(单同领), Lan DL, Li LL, Wang CM, Cui L, Zhang W, Hua XG, Zhu CX, Zhao W, Delwart E. Genomic characterization and high prevalence of bocaviruses in swine. PLoS One. 2011, 6(4): e17292. SCI, IF=4.41

3.?Shan T(单同领), Wang C, Cui L, Yu Y, Delwart E, Zhao W, Zhu C, Lan D, Dai X, Hua X. Picornavirus salivirus/klassevirus in children with diarrhea, China. Emerg Infect Dis. 2010, 6(8):1303-5. SCI, IF=6.859

4.?Zhang Y, Li F, Shan TL(单同领)(通讯作者), Deng X, Delwart E, Feng XP. A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients.?Sci Rep. 2016, 25; 6:26739SCI, IF=5.3

5.?Shan TL(单同领), Wang CM, Cui L, Delwart E, Yuan CL, Zhao W, Guo W, Dai XQ, Yu Y, Hua XG. Human parechovirus infections in monkeys with diarrhea, China. Emerg Infect Dis. 2010, 16(7):1168-9. SCI, IF=6.859

6.?Tongling Shan(单同领), Chunmei Wang, Wu Tong, Hao Zheng, Xiuguo Hua, Shen Yang, Yifei Guo, Wen Zhang, Guangzhi Tong. Complete Genome of a Novel Porcine Astrovirus. J Virol, 2012; Accept. SCI, IF=5.4

7.?Shan TL(单同领), Zhang W, Guo W, Cui L, Yuan CL, Dai XQ, Shen Q, Yang ZB, Zhu JG, Hua XG. The first detection of human bocavirus 2 infections in China. J Clin Virol. 2009, 46(2):196-7. SCI, IF=4.023

8.?Shan TL(单同领), Guo W, Cui L, Shang XG, Dai XQ, Yuan CL, Yu Y, Zhang W, Zhu JG, Shen Q, Yang ZB, Hua XG. The first detection of human parechovirus infections in China. J Clin Virol. 2009, 5(4):371-2. SCI, IF=4.023

9.?Shan TL(单同领), Dai XQ, Guo W, Zhang W, Cui L, Yuan CL, Shang XG, Shen Q, Hua XG. Human astrovirus infection in children with gastroenteritis in Shanghai. J Clin Virol. 2009, 44(3):248-9. SCI, IF=4.023

10.?Shan TL(单同领), Cui L, Dai XQ, Guo W, Shang XG, Yu Y, Zhang W, Kang YJ, Shen Q, Yang ZB, Zhu JG, Hua XG. Sequence analysis of an isolate of minute virus of canines in China reveals the closed association with bocavirus. Mol Biol Rep. 2010, 37(6):2817-20. SCI, IF=1.875

11.?Shan TL(单同领), Tang ZL, Guo DZ, Yang SL, Mu YL, Ma YH, Guan WJ, Li K. Partial molecular cloning, characterization, and analysis of the subcellular localization and expression patterns of the porcine OTUB1 gene. Mol Biol Rep. 2009, 36(6):1573-7. SCI, IF=1.875

12.?Shan TL(单同领), Li K, Tang ZL, Yang SL, Ma YH, Guan WJ, Guo DZ. Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes. Mol Biol Rep. 2009, 36(4):751-6. SCI, IF=1.875

13.?Zhu CX*, Shan TL*(单同领)(*共同一作), Cui L, Luo XN, Liu ZJ, Tang SD, Liu ZW, Yuan CL, Lan DL, Zhao W, Hua XG. Molecular detection and sequence analysis of feline Torque teno virus (TTV) in China. Virus Res. 2011, 56:13-6. SCI, IF=2.905

14.?Yu Y*, Shan T*(单同领)(*共同一作), Zhu S, Zhu C, Hua X, Wang C. Prokaryote expression of HPeV-1 VP1 protein, production of VP1 polyclonal antibody and the development of an ELISA.?J Virol Methods. 2012182(1-2):56-61. SCI, IF=2.139.

15.?Kong N, Meng Q, Wu Y, Wang Z, Zuo Y, Tong W, Zheng H, Li G, Yang S, Yu H,Shan T, (单同领)(通讯作者) Zhou EM,?Tong G. Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 Protein of Swine.. Monoclon Antib Immunodiagn Immunother. 2016;35(3):172-6

16.?Pan X, Kong N, Shan T(单同领)(通讯作者), Zheng H, Tong W, Yang S, Li G, Zhou E, Tong G. Monoclonal antibody to N protein of porcine epidemic diarrhea virus. Monoclon Antib Immunodiagn Immunother.?2015; 34(1):51-4.

17.?Kong N, Wu Y, Meng Q, Wang Z, Zuo Y, Pan X, Tong W, Zheng H, Li G, Yang S, Yu H, Zhou EM,?Shan T(单同领)(通讯作者),?Tong G.. Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway.?PLoS One. 2016,25;11(8):e0161508

18.?Kong N, Meng Q, Wu Y, Wang Z, Zuo Y, Tong W, Zheng H, Li G, Yang S, Yu H,Shan T(单同领)(通讯作者), Zhou EM,?Tong G. Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 Protein of Swine.?Monoclon Antib Immunodiagn Immunother. 2016,35(3):172-6.

19.?Qi D,?Shan T*(单同领)(*共同一作), Liu Z, Deng X, Zhang Z, Bi W, Owens JR, Feng F, Zheng L, Huang F, Delwart E, Hou R, Zhang W. A novel polyomavirus from the nasal cavity of a giant panda (Ailuropoda melanoleuca).?Virol J. 2017 Oct 27; 14(1):207.

20.?Zhang Y, Li F, Chen X, Shan TL(单同领)(通讯作者), Deng XT, Delwart E, Feng XP. Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis.?Virus Genes. 2017 Sep 2. doi: 10.1007/s11262-017-1505-4.

21.?Wang H, Li S, Mahmood A, Yang S, Wang X, Shen Q,?Shan T(单同领)(通讯作者), Deng X, Li J, Hua X, Cui L, Delwart E, Zhang W. Plasma virome of cattle from forest region revealed diverse small circular ssDNA viral genomes.?Virol J. 15(1):11.

22.?Yan?Wang, Wen?Zhang, Zhijian?Liu, Xingli?Fu, Jiaqi?Yuan, Jieji?Zhao, Yuan?Lin, Quan?Shen, Xiaochun?Wang, Xutao?Deng, Eric?Delwart, Tongling?Shan(单同领)(通讯作者). Full-length and defective enterovirus G genomes with distinct torovirus protease insertions are highly prevalent on a Chinese pig farm. Archives of Virology. 2018. online.

23.?Li L, Shan T(单同领), Wang C, C?té C, Kolman J, Onions D, Gulland FM, Delwart E. The fecal viral flora of california sea lions. J Virol. 2011; 85(19):9909-17. SCI, IF=5.189

24.?Wang C, Shan T(单同领), Zheng H, Tong W, Chen F, Hu H, He Q, Tong G. Complete genome sequence of a novel human parechovirus.?J Virol. 2012;86(21):11945-6 SCI, IF=5.4

25.?Li L, Shan T(单同领), Soji OB, Alam MM, Kunz TH, Zaidi SZ, Delwart E. Possible cross-species transmission of circoviruses and cycloviruses among farm animals. J Gen Virol. 2011, 92:768-72. SCI, IF=3.568

26.?Zhang W, Yang S,?Shan T(单同领), Hou R, Liu Z, Li W, Guo L, Wang Y, Chen P, Wang X, Feng F, Wang H, Chen C, Shen Q, Zhou C, Hua X, Cui L, Deng X, Zhang Z, Qi D, Delwart E. Virome comparisons in wild-diseased and healthy captive giant pandas.?Microbiome. 2017 Aug 7;5(1):90. doi: 10.1186/s40168-017-0308-0

27.?Li L, Pesavento P, Shan T(单同领), Leutenegger CM, Wang C, Delwart E. Viruses in diarrhetic dogs include novel kobuviruses and sapoviruses. J Gen Virol. 2011. 92(Pt 11):2534-41. SCI, IF=3.568

28.?Zhu CX, Cui L, Shan TL(单同领), Luo XN, Liu ZJ, Yuan CL, Lan DL, Zhao W, Liu ZW, Hua XG. Porcine torque teno virus infections in China. J Clin Virol. 2010, 48(4):296-8. SCI, IF=4.023

29.?Zheng H, Shan T(单同领), Deng Y, Sun C, Yuan S, Yin Y, Tong G.. Molecular characterization of Japanese encephalitis virus strains prevalent in Chinese swine herds. Journal of Veterinary Science, 2013;14(1):27-36. SCI, IF=1.2

30.?Deng Y, Shan TL(单同领), Tong W, Zheng XC, Guo YY, Zheng H, Cao SJ, Wen XT, Tong GZ. Genomic characterization of a bovine viral diarrhea virus 1 isolate from swine.?Arch Virol. 2014;159(9):2513-7.

31.?Dai XQ, Hua XG, Shan TL(单同领), Delwart E, Zhao W. Human cosavirus infections in children in China. J Clin Virol. 2010, 48(3):228-9. SCI, IF=4.023

32.?Lan D, Ji W, Shan T(单同领), Cui L, Yang Z, Yuan C, Hua X. Molecular characterization of a porcine astrovirus strain in China.?Arch Virol. 2011, 156(10):1869-75. SCI, IF=2.209

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